Sicily, 1880. When a stranger arrives in Vigàta, the town's inhabitants immediately become unsettled. It seems the young man, Fofo, is the son of a local peasant legendary for his home-grown medicines; a man who was murdered many years before. Fofo opens his own pharmacy in Vigàta and his remedies are sought by many. But he soon finds himself entangled with Don Filippo, a philandering marchese, and his family. It won't be long before death visits Vigàta, and the town and its most noble family will never be the same again...