In midtown Manhattan, Mike Hammer, recovering from a near-fatal mix-up with the Mob, runs into drug dealers assaulting a young hospital messenger. He saves the kid, but the muggers are not so lucky. Hammer considers the rescue a one-off, but someone has different ideas, as indicated by a street-corner knife attack. With himself for a client, Hammer—and his beautiful, deadly partner Velda—take on the narcotics racket in New York just as the streets have dried up and rumors run rampant of a massive heroin shipment due any day. In a New York of flashy discotheques, swanky bachelor pads, and the occasional dark alley, Hammer deals with doctors and drug addicts, hippie chicks and hit men, meeting changing times with his timeless brand of violent vengeance.

Originally begun and outlined by Spillane in the mid-sixties, and expertly completed by his longtime collaborator Max Allan Collins, The Big Bang is vintage Mike Hammer on acid—literally.