The essays discuss continuity and change in Bilād al Shām (Greater Syria) during the sixteenth century, examining to what extent Egypt and Greater Syria were affected by the transition from Mamluk to Ottoman rule. This is explored in a variety of areas: diplomatic relations, histories and historiography, fiscal and agricultural administration, symbolic orders, urban developments, local perspectives and material culture. In order to rethink the sixteenth century from a transitional perspective and thus overcome the conventional dynasty-centered fields of research Mamlukists and Ottomanists have been brought together, shedding light on the remarkable sixteenth century, so decisive for the formation of early modern Muslim empires.