When the whole universe gets fog to kill breeding of Mosquitoes, and fishes are placed in all of the rivers and lakes where mosquitoes lay. Niagara and the other mosquitoes who survive have to come up with a plan to stop the wicked humans from trying to kill them all, but when the scientists experiments turn into a disaster, a whole new breed of mosquitoes are born and the scientists have to find a way to destroy the new breed of mosquitoes before the humans become extinct.