Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantialburden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significanteconomic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at theclinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.