In quest of the unpublished manuscript of a martyred Yiddish writer, the American novelist Nathan Zuckerman travels to Soviet-occupied Prague in the mid-1970s. There, in a nation straightjacketed by totalitarian Communism, he discovers a literary predicament, marked by institutionalized oppression, that is rather different from his own. He also discovers, among the oppressed writers with whom he quickly becomes embroiled in a series of bizarre and poignant adventures, an appealingly perverse kind of heroism.

The Prague Orgy, consisting of entries from protagonist Nathan Zuckerman's notebooks recording his sojourn among these outcast artists, completes the Nathan Zuckerman series. It provides a startling ending to Roth's intricately designed magnum opus on the unforeseen consequences of art.