With the aid of his elite squad of super cops, NYPC captain Tony Mace has defeated the werewolf slayers known as the Brotherhood of Torquemada. But now a new enemy has risen to persecute the peaceful Wolves, and Tony's loyalty to Gabriel Domini, leader of the pack, places him at odds with his department.
Gabriel's brother Raphael objects to Gabriel's efforts to integrate the Wolves into human society, and seeks to start a war against mankind. When Rodrigo Gomez, the Full Moon Killer, escapes from prison, his quest for vengeance draws Tony into a battle for supremacy among the Wolves which could lead to a far greater war for both species.