When Willow is born with severe osteogenesis imperfecta, her parents are devastated—she will suffer hundreds of broken bones as she grows, a lifetime of pain. In this provocative story from the #1 New York Times bestselling author, "Picoult writes with unassuming brilliance" (Stephen King).
Every expectant parent insists the same thing: they simply want a healthy baby. Charlotte and Sean O'Keefe wanted the same but instead, their lives are made up of sleepless nights, mounting bills, pity from other parents, and haunting what-ifs.

Yet, in other ways, their daughter Willow is a perfect child. Smart as a whip, beautiful, brave, and kind, Willow is Willow, in sickness and in health.

Everything changes, though, after a series of events forces Charlotte and Sean to confront the most serious what-ifs of all. What if Charlotte had known earlier of Willow's illness? What if things could have been different? What if their beloved Willow had never been born? To do Willow justice, Charlotte must ask herself these questions and one more: what constitutes a valuable life?

"Well-written and conscientiously researched" (The Washington Post), Handle with Care is an unforgettable and emotionally riveting novel that explores the fragility of life and the lengths we go to protect it.