In Patricia Highsmith's debut novel, we encounter Guy Haines and Charles Anthony Bruno, passengers on the same train. But while Guy is a successful architect in the midst of a divorce, Bruno turns out to be a sadistic psychopath who manipulates Guy into swapping murders with him. As Bruno carries out his twisted plan, Guy is trapped in Highsmith's perilous world—where, under the right circumstances, anybody is capable of murder.

The inspiration for Alfred Hitchcock's classic 1951 film, Strangers on a Train launched Highsmith on a prolific career of noir fiction, and proved her mastery of depicting the unsettling forces that tremble beneath the surface of everyday contemporary life.